History of Creation Viagra

History of Creation Viagra (The little blue pill)

Viagra is only a sonorous name. In fact, small lozenge-shaped tablets with the inscription “VGR 25”, “VGR 50” or “VGR 100” on one side and “Pfizer” on the other are Sildenafil Citrate. The numbers on the tablets indicate the active ingredient content in milligrams.

Viagra is a remedy for eliminating erectile dysfunction. That is, in order to take it, you need, as a minimum, to diagnose these violations. Experts define erectile dysfunction as “a pathological condition in which the quality of erections in men decreases and, as a consequence, the inability to conduct a sufficient sexual intercourse”.

Usually this kind of problem happens to men after 40 years old. However, recently, problems with erection arise in very young people. The emergence of such disorders is facilitated by stresses obtained in the struggle for survival, excessive consumption of alcohol, smoking of low-quality tobacco. But also, erectile dysfunction is a common phenomenon. So, as a result of a survey of men in Massachusetts, sociologists found that 52% of respondents have problems with erection.

Discovery of the Main Active Substance-Sildenafil

Many people will remember the twentieth century not only as an age of technological progress or conquest of the cosmos, but also as the age of discovery of Viagra or Sildenafil. The men of the whole planet were encouraged by the appearance of this pharmaceutical product, although many do not talk about it out loud.

Initially, Viagra was designed to treat high blood pressure. However, during clinical trials, men who used this medicine told doctors about the same side effect of its use, which was expressed in a prolonged and elevated erection. But for initial use aim, Viagra online was almost ineffective, so the doctors decided to completely transfer the focus of the appointment of this drug to men suffering from erectile dysfunction. And it worked massively! Since March 27, 1998, Viagra has been approved by the FDA for this particular use.

After that, the company Pfizer began actively working on improving the drug. It was given the official name of Viagra, and the main substance was Sildenafil. The name comes from a combination of the letters of two words: Vigor – power and Niagara – the largest waterfall in North America. The invention of Viagra can be deservedly ranked among the great discoveries in medicine, which were discovered by chance.

Directions of Use of the Substance

Drugs containing the substance Sildenafil, are potent vasodilators. Sildenafil is used to treat erectile dysfunction in men, as well as to normalize the natural response to sexual arousal. The most famous drug based on Sildenafil is Viagra.

In addition, due to its vasodilating effect, Sildenafil is able to reduce pressure in the pulmonary artery, which is used to treat people suffering from pulmonary hypertension. Therefore, the main directions of Sildenafil use are the treatment of erectile dysfunction and pulmonary hypertension.

viagra usage

Effect on the Heart Muscle

Sildenafil, a well-known drug for the treatment of erectile dysfunction, was originally created for use in cardiology. Today, it is sometimes prescribed for cardiovascular disease. However, animal experiments conducted at the Johns Hopkins University have shown that this medicine can have different effects on women and men.

Sildenafil, an inhibitor of type 5 phosphodiesterase (PDE-5), acts by dilating the blood vessels, and improves blood circulation. In the case of erectile dysfunction, this leads to increased blood filling of the penis. The effect of this drug is essentially similar to the effect of nitrates, which are widely used in angina pectoris. Recent studies have confirmed the positive effect of Sildenafil on the heart muscle, so today, scientists are studying the possibility of its use in heart failure.

What Connection in Heart and Erectile Function

Atherosclerosis affects the aorta and other large vessels, coronary, renal, cerebral and peripheral arterial nets and is manifested by vascular diseases of the heart, kidneys, brain and peripheral basin. In addition, in the initial stages of the progression of atherosclerosis, various physiological processes and functions may occur, such as, for example, erectile dysfunction (ED) in men.

The first link in the development of atherosclerosis is endothelial dysfunction. Since the erection of the penis depends critically on endothelial function, endothelial dysfunction can lead to ED – the inability to achieve and maintain an erection sufficient for a successful sexual intercourse. Accordingly, ED is closely related to common cardiovascular risk factors, such as hypercholesterolemia, diabetes mellitus, hypertension and obesity.

Earlier it was believed that the main causes of ED are psychological factors. However, over the past two decades, it has been established that the leading causes for problems

 

The Availability and Use of the Drug at the Dawn of Creation

And as a logical finale – on March 27, 1998, the US Department of Food and Drug Administration approved the use of Viagra. From this moment Viagra began its victorious offensive march across the world and during this short time literally blew up the planet.

The fuss was squalid. During the first week of receipt of the drug for sale on Viagra, 247,666 prescriptions were written. The second week the number of the men who wanted to get Viagra increased by more than 50,000. As a result, only in 1998 the company Pfizer sold Viagra for 1 billion dollars.

The effect of the drug “Viagra” was evaluated by more than 3000 men aged 19 to 87 years in studies of erectile dysfunctions conducted in all countries of the world. The duration of erectile dysfunction in these patients averaged 5 years (from 6 months to 26 years), and erectile dysfunction was organic, psychogenic and mixed organic as well as psychogenic.

The results of these studies proved the effectiveness of Viagra for restoring healthy erections and improving the rates of successful sexual intercourse in many patients, among them there were many diabetics, with damage of the spinal cord, other concomitant clinical conditions, and patients taking multiple medications simultaneously.